Knowledge, attitudes and modelling of refusal to vaccinate children by users of the Expanded Programme on Immunisation in Côte d'Ivoire during COVID-19.
DOI:
https://doi.org/10.4314/rasp.v7i2.11Keywords:
Expanded Programme on Immunisation, vaccine refusal, predictive factorsAbstract
The COVID-19 pandemic has profoundly affected perceptions of childhood vaccination in Côte d'Ivoire, leading to disruptions in the Expanded Program on Immunization (EPI). This study aims to identify factors associated with vaccination refusal during this period. This study is based on a descriptive and analytical survey conducted among 422 users of the Expanded Program on Immunization between April 26 and May 14, 2021 at the National Institute of Public Hygiene. The target population consisted of parents of children aged 0 to 11 months, attending the center for at least six months. Data were collected using a questionnaire on sociodemographic characteristics, attitudes, and perceptions towards COVID-19 and vaccination. A descriptive analysis, supplemented by logistic regression, was carried out to identify knowledge levels, attitudes, and model factors associated with vaccination refusal. The results reveal that 46.68% of parents were hesitant about vaccination. Geographic variations were observed: general fear of vaccination predominated in Abobo, Yopougon, and Port-Bouët, while fear of substitution by the COVID-19 vaccine was more pronounced in Cocody and Treichville. Six factors were identified as predictors of refusal, including fear of side effects (aOR = 3.63) and fear of receiving a COVID-19 vaccine (aOR = 6.57). These results underscore the importance of strengthening communication to rebuild vaccine confidence.
References
Chippaux JP. (2023). Impact de la COVID-19 sur la santé publique en Afrique subsaharienne, .Bulletin de l'Académie Nationale de Médecine.2023;207:150-164. (https://www.sciencedirect.com/science/article/pii/S0001407922003697//doi.org/10.1016/j.banm.2022.10.015.
Cooper S, van Rooyen H, Wiysonge CS. (2021). COVID-19 vaccine hesitancy in South Africa: how can we maximize uptake of COVID-19 vaccines? Expert Rev Vaccines. 2021;20(8):921-933. https://doi.org/10.1080/14760584.2021.1949291
Cox DR. (1958). The regression analysis of binary sequences. Journal of the Royal Statistical Society: Series B (Methodological), 20(2), 215–242.
Ditekemena JD, Nkamba DM, Mutwadi A, Mavoko MH, Fodjo JNS, Luhata C, Michael, Colebunders R .(2021). COVID-19 vaccine acceptance in the Democratic Republic of Congo: a cross-sectional survey. Vaccines (Basel). 2021;9(2):153.
https://doi.org/10.3390/vaccines9020153
Dubé E, Ward JK, Verger P, MacDonald NE. (2021). Vaccine hesitancy, acceptance, and anti-vaccination: trends and future prospects for public health. Annu Rev Public Health. 2021;42:175-91. https://doi.org/10.1146/annurev-publhealth-090419-102240
Hosmer DW, Lemeshow S. (1980). Goodness of fit tests for the multiple logistic regression model. Communications in Statistics - Theory and Methods, 9(10), 1043–1069.
Larson HJ, Hartigan-Go K, de Figueiredo A. (2020). Vaccine hesitancy: origins, trends, and pathways forward. Hum Vaccin Immunother. 2020;16(12):2584-94.
Larson HJ, Jarrett C, Eckersberger E, Smith DMD, Paterson P. (2014). Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: a systematic review of published literature, 2007–2012. Vaccine. 2014;32(19):2150-2159. DOI : 10.1016/j.vaccine.2014.01.081
Ndiaye P, Dia AT, Hanon S, Tal-Dia A. (2022). Impact de la pandémie COVID-19 sur les programmes de vaccination en Afrique de l’Ouest : état des lieux et perspectives. Rev Afr Santé Publique. 2022;19(3):45-58.
Olanipekun T, Olusanya J, Oluwaranti A. (2022). Hesitancy towards childhood immunization in Nigeria: a review of the literature and policy recommendations. BMC Public Health. 2022;22:1176.
Rubin DB, (1987). Multiple Imputation for Nonresponse in Surveys. New York: John Wiley & Sons.
Sallam M. (2021). COVID-19 vaccine hesitancy worldwide: a concise systematic review of vaccine acceptance rates. Vaccines (Basel). 2021;9(2):160.
Wilson SL, Wiysonge C. (2020). Social media and vaccine hesitancy. BMJ Global Health. 2020;5(10):e004206.
World Health Organization (2014). Report of the SAGE Working Group on Vaccine Hesitancy. November 2014
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Meless Djedjro Franck Renaud, Yassi Léonce Olivier Assi, N’Dri Kouamé Mathias, Attoh Toure Harvey, Amin Ncho Christophe

This work is licensed under a Creative Commons Attribution 4.0 International License.
https://creativecommons.org/licenses/by/4.0/
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms